Evaluation of the Surgical and Pharmacological Treatment of Diabetic Foot Infection: A Retrospective Study

BACKGROUND: Diabetic foot infection is a major cause of patient disabilities and lowers limb amputations, with high treatment costs and hospitalisation requirements. AIM: Aim of this study was to evaluate surgical wound care plus antibiotic effects in the treatment of mild and moderate diabetic foot infections. METHODS: This retrospective study involved 60 patients with diabetic foot infections with or without osteomyelitis. The patients were categorised as group 1 mild and group 2 moderate. Both groups were treated using local wound debridement and the systemic administration of antibiotics. Group 1 (16) patients were treated with two regimens of oral antibiotics in two regimens, A (amoxicillin/clavulanate + metronidazole) and B (clindamycin + metronidazole), for 10-14 days. Group 2 (42) patients were treated with oral plus intravenous antibiotics in two regimens, A (ampicillin + cloxacillin + metronidazole) and B (lincomycin + metronidazole), for 6 weeks. The patients followed-up with local wound care specialists for 3 months to evaluate the treatment outcomes (cure, improvement, or failure). RESULTS: Group 1 had an 80% cure rate under regimen A and a 100% cure rate under regimen B. Group 2 regimen A patients had a 61.5% cure rate and 11.53% improved, while regimen B patients had a 68.75% cure rate and 12.5% improved. Failure in both regimens was 23.8% in 20 patients with osteomyelitis, while 35% were cured and 20% improved during the study period. CONCLUSION: Local surgical wound care for 3 months with antibiotic regimens for 6 weeks resulted in good response and cure rates, with lower costs and fewer instances of hospitalisation. Intravenous lincomycin and oral metronidazole achieved higher cure responses for moderate diabetic foot infections

Evaluation of the Surgical and Pharmacological Treatment of Diabetic Foot Infection: A Retrospective Study

BACKGROUND: Diabetic foot infection is a major cause of patient disabilities and lowers limb amputations, with high treatment costs and hospitalisation requirements. AIM: Aim of this study was to evaluate surgical wound care plus antibiotic effects in the treatment of mild and moderate diabetic foot infections. METHODS: This retrospective study involved 60 patients with diabetic foot infections with or without osteomyelitis. The patients were categorised as group 1 mild and group 2 moderate. Both groups were treated using local wound debridement and the systemic administration of antibiotics. Group 1 (16) patients were treated with two regimens of oral antibiotics in two regimens, A (amoxicillin/clavulanate + metronidazole) and B (clindamycin + metronidazole), for 10-14 days. Group 2 (42) patients were treated with oral plus intravenous antibiotics in two regimens, A (ampicillin + cloxacillin + metronidazole) and B (lincomycin + metronidazole), for 6 weeks. The patients followed-up with local wound care specialists for 3 months to evaluate the treatment outcomes (cure, improvement, or failure). RESULTS: Group 1 had an 80% cure rate under regimen A and a 100% cure rate under regimen B. Group 2 regimen A patients had a 61.5% cure rate and 11.53% improved, while regimen B patients had a 68.75% cure rate and 12.5% improved. Failure in both regimens was 23.8% in 20 patients with osteomyelitis, while 35% were cured and 20% improved during the study period. CONCLUSION: Local surgical wound care for 3 months with antibiotic regimens for 6 weeks resulted in good response and cure rates, with lower costs and fewer instances of hospitalisation. Intravenous lincomycin and oral metronidazole achieved higher cure responses for moderate diabetic foot infections

Inclusive and differential cross section measurements of ttˉbbˉ {\mathrm{t}\bar{\mathrm{t}}} \mathrm{b}\bar{\mathrm{b}} production in the lepton+jets channel at s= \sqrt{s}= 13 TeV

Measurements of inclusive and normalized differential cross sections of the associated production of top quark-antiquark and bottom quark-antiquark pairs, ${\mathrm{t}\bar{\mathrm{t}}} \mathrm{b}\bar{\mathrm{b}}$, are presented. The results are based on data from proton-proton collisions collected by the CMS detector at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb$^{-1}$. The cross sections are measured in the lepton+jets decay channel of the top quark pair, using events containing exactly one isolated electron or muon and at least five jets. Measurements are made in four fiducial phase space regions, targeting different aspects of the ${\mathrm{t}\bar{\mathrm{t}}} \mathrm{b}\bar{\mathrm{b}}$ process. Distributions are unfolded to the particle level through maximum likelihood fits, and compared with predictions from several event generators. The inclusive cross section measurements of this process in the fiducial phase space regions are the most precise to date. In most cases, the measured inclusive cross sections exceed the predictions with the chosen generator settings. The only exception is when using a particular choice of dynamic renormalization scale, ${\mu_{\mathrm{R}}=\frac12 \prod_{i=\mathrm{t},\bar{\mathrm{t}},\mathrm{b},\bar{\mathrm{b}}} m_{\mathrm{T},i}^{1/4}}$, where ${m_{\mathrm{T},i}^2=m_i^2+p_{\mathrm{T},i}^2}$ are the transverse masses of top and bottom quarks. The differential cross sections show varying degrees of compatibility with the theoretical predictions, and none of the tested generators with the chosen settings simultaneously describe all the measured distributions.Measurements of inclusive and normalized differential cross sections of the associated production of top quark-antiquark and bottom quark-antiquark pairs, ttbb, are presented. The results are based on data from proton-proton collisions collected by the CMS detector at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb$^{-1}$. The cross sections are measured in the lepton+jets decay channel of the top quark pair, using events containing exactly one isolated electron or muon and at least five jets. Measurements are made in four fiducial phase space regions, targeting different aspects of the ttbb process. Distributions are unfolded to the particle level through maximum likelihood fits, and compared with predictions from several event generators. The inclusive cross section measurements of this process in the fiducial phase space regions are the most precise to date. In most cases, the measured inclusive cross sections exceed the predictions with the chosen generator settings. The only exception is when using a particular choice of dynamic renormalization scale, $\mu_\mathrm{R}=\frac{1}{2} \prod_{i=\mathrm{t, \bar{t}, b, \bar{b}}} m_{\mathrm{T},i}^{1/4}$, where $m_{\mathrm{T},i}^2=m_i^2+p^2_{\mathrm{T},i}$ are the transverse masses of top and bottom quarks. The differential cross sections show varying degrees of compatibility with the theoretical predictions, and none of the tested generators with the chosen settings simultaneously describe all the measured distributions

Search for an exotic decay of the Higgs boson into a Z boson and a pseudoscalar particle in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceA search for an exotic decay of the Higgs boson to a Z boson and a light pseudoscalar particle (a), decaying to a pair of leptons and a pair of photons, respectively, is presented. The search is based on proton-proton collision data at a center-of-mass energy of $\sqrt{s}$ = 13 TeV, collected with the CMS detector and corresponding to an integrated luminosity of 138 fb$^{-1}$. The analysis probes pseudoscalar masses a between 1 and 30 GeV, leading to two pairs of well-isolated leptons and photons. Upper limits at 95% confidence level are set on the Higgs boson production cross section times its branching fraction to two leptons and two photons. The observed (expected) limits are in the range of 1.1-17.8 (1.7-17.9) fb within the probed $m_\mathrm{a}$ interval. An excess of data above the expected standard model background with a local (global) significance of 2.6 (1.3) standard deviations is observed for a mass hypothesis of $m_\mathrm{a}$ = 3 GeV. Limits on models involving axion-like particles, formulated as an effective field theory, are also reported

Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at s= \sqrt{s}= 13 TeV

A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the $\mathrm{p}\mathrm{p}\to \mathrm{t}\mathrm{H}/\mathrm{A} \to\mathrm{t}\mathrm{t}\overline{\mathrm{c}}$ and $\mathrm{p}\mathrm{p}\to \mathrm{t}\mathrm{H}/\mathrm{A} \to\mathrm{t}\mathrm{t}\overline{\mathrm{u}}$ processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb$^{-1}$. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp $\to$ tH/A $\to$ t$\mathrm{\bar{t}}$c and pp $\to$ tH/A $\to$ t$\mathrm{\bar{t}}$u processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb$^{-1}$. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM

Measurement of the Higgs boson production via vector boson fusion and its decay into bottom quarks in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceA measurement of the Higgs boson (H) production via vector boson fusion (VBF) and its decay into a bottom quark-antiquark pair ($\mathrm{b\bar{b}}$) is presented using proton-proton collision data recorded by the CMS experiment at $\sqrt{s}$ = 13 TeV and corresponding to an integrated luminosity of 90.8 fb$^{-1}$. Treating the gluon-gluon fusion process as a background and constraining its rate to the value expected in the standard model (SM) within uncertainties, the signal strength of the VBF process, defined as the ratio of the observed signal rate to that predicted by the SM, is measured to be $\mu^\text{qqH}_\mathrm{Hb\bar{b}}$ = 1.01$^{+0.55}_{-0.46}$. The VBF signal is observed with a significance of 2.4 standard deviations relative to the background prediction, while the expected significance is 2.7 standard deviations. Considering inclusive Higgs boson production and decay into bottom quarks, the signal strength is measured to be $\mu^\text{incl.}_\mathrm{Hb\bar{b}}$ = 0.99$^{+0.48}_{-0.41}$, corresponding to an observed (expected) significance of 2.6 (2.9) standard deviations

Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceA search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp $\to$ tH/A $\to$ t$\mathrm{\bar{t}}$c and pp $\to$ tH/A $\to$ t$\mathrm{\bar{t}}$u processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb$^{-1}$. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM

Muon identification using multivariate techniques in the CMS experiment in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceThe identification of prompt and isolated muons, as well as muons from heavy-flavour hadron decays, is an important task. We developed two multivariate techniques to provide highly efficient identification for muons with transverse momentum greater than 10\GeV. One provides a continuous variable as an alternative to a cut-based identification selection and offers a better discrimination power against misidentified muons. The other one selects prompt and isolated muons by using isolation requirements to reduce the contamination from nonprompt muons arising in heavy-flavour hadron decays. Both algorithms are developed using 59.7 fb$^{-1}$ of proton-proton collisions data at a centre-of-mass energy of $\sqrt{s}$ = 13 TeV collected in 2018 with the CMS experiment at the CERN LHC

Search for new physics in multijet events with at least one photon and large missing transverse momentum in proton-proton collisions at 13 TeV

A search for new physics in final states consisting of at least one photon, multiple jets, and large missing transverse momentum is presented, using proton-proton collision events at a center-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 137 fb$^{-1}$, recorded by the CMS experiment at the CERN LHC from 2016 to 2018. The events are divided into mutually exclusive bins characterized by the missing transverse momentum, the number of jets, the number of b-tagged jets, and jets consistent with the presence of hadronically decaying W, Z, or Higgs bosons. The observed data are found to be consistent with the prediction from standard model processes. The results are interpreted in the context of simplified models of pair production of supersymmetric particles via strong and electroweak interactions. Depending on the details of the signal models, gluinos and squarks of masses up to 2.35 and 1.43 TeV, respectively, and electroweakinos of masses up to 1.23 TeV are excluded at 95% confidence level

Search for an exotic decay of the Higgs boson into a Z boson and a pseudoscalar particle in proton-proton collisions at s\sqrt{s} = 13 TeV

International audienceA search for an exotic decay of the Higgs boson to a Z boson and a light pseudoscalar particle (a), decaying to a pair of leptons and a pair of photons, respectively, is presented. The search is based on proton-proton collision data at a center-of-mass energy of $\sqrt{s}$ = 13 TeV, collected with the CMS detector and corresponding to an integrated luminosity of 138 fb$^{-1}$. The analysis probes pseudoscalar masses a between 1 and 30 GeV, leading to two pairs of well-isolated leptons and photons. Upper limits at 95% confidence level are set on the Higgs boson production cross section times its branching fraction to two leptons and two photons. The observed (expected) limits are in the range of 1.1-17.8 (1.7-17.9) fb within the probed $m_\mathrm{a}$ interval. An excess of data above the expected standard model background with a local (global) significance of 2.6 (1.3) standard deviations is observed for a mass hypothesis of $m_\mathrm{a}$ = 3 GeV. Limits on models involving axion-like particles, formulated as an effective field theory, are also reported